Product Name Galvus Met 50/1000, Reduce Blood Glucose Level & Prevent Diabetes Complications - 60 Tablets Scientific Name Vildagliptin 50 + Metformin 1000 Mg Tablets Category Of Galvus Met 50/1000 Tablets Oral Anti-Diabetic Drugs Mechanism Of Action Of Vildagliptin & Metformin Vildagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1). Incretins help the body produce more insulin only when it is needed and reduce the amount of glucose being produced by the liver when it is not needed. Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis) Metformin decreases the intestinal absorption of glucose Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization Therapeutic Indications Of Galvus Met 50/1000 Tablets It is indicated as an adjunct to diet and exercise to improve glycemic control in patients whose diabetes is not adequately controlled on metformin hydrochloride or vildagliptin alone Method Of Administration Of Galvus Met 50/1000 Tablets It should be given with meals to reduce the gastrointestinal side effects associated with metformin hydrochloride. It may be initiated at 50mg/500 mg once daily and gradually titrated to a maximum dose of 50mg/1000 mg twice daily after assessing the adequacy of therapeutic response Doses higher than 100mg of vildagliptin are not recommended Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions. If you take more than you should, talk to a doctor or go to the hospital straight away. If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose. Do not take a double dose (two doses at the same time) to make up for the forgotten dose. Undesirable Side Effects Of Galvus Met 50/1000 Tablets Although the following side effects are not common in everyone, some patients may complain from: Tremor, dizziness, headache Nausea Hypoglycemia Pregnancy & Breastfeeding Precautions While Taking Galvus Met 50/1000 Tablets If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Your doctor will discuss the possible risks and benefits of using this medicine during pregnancy and breast-feeding Non-Pharmacological Treatments & Advice For Diabetic Patients All carbohydrates affect blood glucose levels so it’s important to know which foods contain carbohydrates. Choose the healthier foods that contain carbs and be aware of your portion sizes. Eat less salt. Eating lots of salt can increase your risk of high blood pressure, which in turn increases the risk of heart diseases and stroke. And when you have diabetes, you’re already more at risk of all of these conditions. Eat more fruit and vegetables. This can help you get the vitamins, minerals, and fiber your body needs every day to help keep you healthy. You can always try low or zero-calorie sweeteners (also known as artificial sweeteners) to help you cut down sugar for example Steviana Sweetener or Tropicana Slim Sweetener Don’t forget to keep moving. Being more physically active goes hand in hand with eating healthier. Remember to measure your blood glucose level continuously by using home monitor like Accu-Check, Instant, Blood Glucose Monitor Thiozac Capsules & Neurobion Tablets will help you to reduce neuropathy induced by diabetes If you experience symptoms of hypoglycemia such as weakness, dizziness, increased sweating, fast heart beating, vision disorders, or difficulty in concentration, it usually helps to eat or drink something containing sugar. Warnings & Special Precautions While Taking Galvus Met 50/1000 Tablets Talk to your doctor or pharmacist before taking it if you have: Hypersensitivity to vildagliptin or metformin hydrochloride or any of the excipients If you have moderate or severe liver problems Severe renal impairment Congestive heart failure Acute or chronic metabolic acidosis, including lactic acidosis or diabetic ketoacidosis Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications including over-the-counter non-prescription medicines, prescription medicines, herbal supplements, vitamins, and supplements. Storage Conditions Of Galvus Met 50/1000 Tablets Store below 25°c Don’t refrigerate Keep this medicine out of the sight and reach of children. Store in the original package to protect from moisture. Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month. Normal Ranges Random blood sugar test: A blood sample will be taken at a random time. Regardless of when you last ate, a blood sugar level of 200 milligrams per deciliter (mg/dL) or higher suggests diabetes. A blood sugar level of less than 140 mg/dL is normal. A reading between 140 and 199 mg/dL indicates prediabetes Fasting blood sugar test. A blood sample will be taken after an overnight fast. A fasting blood sugar level of less than 100 mg/dl is normal. A fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes. If it's 126 mg/dL or higher on two separate tests, you may have diabetes. Oral glucose tolerance test: For this test, you fast overnight, and the fasting blood sugar level is measured. Then you drink a sugary liquid, and blood sugar levels are tested periodically for the next two hours.