Medication for muscle spasms and spasms Active Ingredient : tizanidine Pharmacological Classification: Alpha2-Adrenergic Agonist Indications: Muscle spasm and/or musculoskeletal pain (adjunctive therapy) How to use: Take orally once daily 2 to 4 mg every 8 to 12 hours or at bedtime The full daily dose should not exceed 16 mg Dosages vary for each patient, so you should refer to your doctor and follow-up continuously Do not take the medicine if: If you are allergic to tizanidine, alpha agonists, or any of the ingredients in this medicine Kidney failure Liver failure Elderly people over 65 years of age (may be prescribed and used with caution according to the doctor's instructions) he level of drug absorption may change in the case of fasting, so follow-up and advice should be given regarding this The effect of the medicine may interfere or be affected with contraceptive medicines (consult the doctor or pharmacist). Please read the internal leaflet also for possible additional contraindications The most important side effects (with common risk factors): Asymptomatic increase in liver enzymes (the most important risk factor is people with latent hepatic insufficiency) Low blood pressure and may lead to weakness, dizziness or fainting (usually appears with high doses, taking the drug with drugs that inhibit liver enzymes such as some antibiotics, taking the drug with some antihypertensive drugs, latent liver failure). sedation (usually with high doses and can occur within 60 minutes, especially with alcohol users, taking the drug with drugs that inhibit liver enzymes such as some antibiotics) Withdrawal syndrome including hallucinations, high blood pressure, nausea, tremors and tachycardia (sudden discontinuation of the drug without prior dose grading, use of high hunger, prolonged use of the drug) dry mouth Dizziness, drowsiness, and weakness warning : Treatment should not be stopped abruptly, but should be reduced gradually to avoid effective withdrawal symptoms, especially for patients with a previous medical history of heart, liver and kidney disease. Pregnancy and lactation: A doctor should be consulted in case of pregnancy and breastfeeding. Storage: • Store at a temperature not exceeding 30°C.