Mechanism Of Action Of Metformin Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis) Metformin decreases the intestinal absorption of glucose Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization Therapeutic Indications Of Formit Xr 750 Mg Tablets Metformin hydrochloride is used to treat patients with type 2 diabetes (also called non-insulin-dependent diabetes) when diet and exercise alone have not been enough to control your blood glucose levels. Diabetes Mellitus is a lifelong condition that causes a person's blood sugar level to become too high The main symptoms of diabetes mellitus are polyuria, polyphagia & polydipsia Method Of Administration Of Formit Xr 750 Mg Tablets The dosage of Metformin is determined by the doctor on an individual basis according to the results of laboratory blood glucose measurement. Usually, adults start with 500 mg or 850 mg metformin hydrochloride 2 or 3 times a day. The maximum daily dose is 3000 mg taken as 3 divided doses Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions. If you take more than you should, talk to a doctor or go to the hospital straight away. If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose. Do not take a double dose (two doses at the same time) to make up for the forgotten dose. Undesirable Side Effects Of Formit Xr 750 Mg Tablets Although the following side effects are not common in everyone, some patients may complain from: Gastrointestinal discomfort such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite may occur especially at the beginning of treatment. These symptoms are generally transient and can be reduced by taking the tablets with meals. If symptoms persist, the patients should stop taking the treatment and consult their doctor. Taste disturbance Lactic acidosis is a very serious complication, which results in vomiting, abdominal pain with muscle cramps, and/or a general feeling of malaise with severe fatigue and which requires specific treatment. If this occurs, patients should stop taking the drug immediately and consult their doctor promptly. Lactic acidosis is a medical emergency and must be treated in a hospital. Skin reactions such as erythema (red skin), itching, or urticaria (eruption with itching). Decreased vitamin B12 levels (to take into consideration if the patient is suffering from megaloblastic anemia). Isolated cases of liver function test abnormalities or hepatitis resolving upon discontinuation of the drug Pregnancy & Breastfeeding Precautions While Taking Formit Xr 750 Mg Tablets If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Your doctor will discuss the possible risks and benefits of using this medicine during pregnancy and breast-feeding Non-Pharmacological Treatments & Advice For Diabetic Patients All carbohydrates affect blood glucose levels so it’s important to know which foods contain carbohydrates. Choose the healthier foods that contain carbs and be aware of your portion sizes. Eat less salt. Eating lots of salt can increase your risk of high blood pressure, which in turn increases the risk of heart diseases and stroke. And when you have diabetes, you’re already more at risk of all of these conditions. Eat more fruit and vegetables. This can help you get the vitamins, minerals, and fiber your body needs every day to help keep you healthy. You can always try low or zero-calorie sweeteners (also known as artificial sweeteners) to help you cut down sugar for example Steviana Sweetener or Tropicana Slim Sweetener Don’t forget to keep moving. Being more physically active goes hand in hand with eating healthier. Remember to measure your blood glucose level continuously by using home monitor like Accu-Check, Instant, Blood Glucose Monitor Thiozac Capsules & Neurobion Tablets will help you to reduce neuropathy induced by diabetes If you experience symptoms of hypoglycemia such as weakness, dizziness, increased sweating, fast heart beating, vision disorders, or difficulty in concentration, it usually helps to eat or drink something containing sugar. Warnings & Special Precautions While Taking Formit Xr 750 Mg Tablets Do not take metformin hydrochloride: If you are allergic to metformin hydrochloride or any of the other ingredients of this medicine If you have liver problems If you have severely reduced kidney function If you have uncontrolled diabetes, with, for example, severe hyperglycemia, nausea, vomiting, diarrhea, rapid weight loss If you have a severe infection, such as an infection affecting your lung or bronchial system or your kidney If you are treated for acute heart failure or have recently had a heart attack, have severe problems with your circulation, or have breathing difficulties If you take metformin hydrochloride together with other medicines to treat diabetes, that can cause hypoglycemia. If you experience symptoms of hypoglycemia such as weakness, dizziness, increased sweating, fast heart beating, vision disorders, or difficulty in concentration, it usually helps to eat or drink something containing sugar. Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications including over-the-counter non-prescription medicines, prescription medicines, herbal supplements, vitamins, and supplements. Storage Conditions Of Formit Xr 750 Mg Tablets Store below 25°c Don’t refrigerate Keep this medicine out of the sight and reach of children. Store in the original package to protect from moisture. Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.