What Progesterone is used for Progesterone is a natural, female sex hormone, produced in the body. It works by adjusting the hormonal balance within the body for the treatment of: • pre-menstrual syndrome which often affects women during the 7 to 10 days before their monthly period. • post-natal depression which some women get after their baby has been born. Do not use Progesterone if you: • are allergic to progesterone or any of the other ingredients of this medicine, • have unusual vaginal bleeding that has not been evaluated by the doctor, • have known or suspected tumor that is hormone sensitive, • have porphyria disorders (a group of inherited or acquired disorders of certain enzymes), • have or have had blood clots in the legs, lungs, eyes or elsewhere in the body, • currently have or have had severe liver problems. • have a miscarriage and your physician suspects some tissue is still in the uterus or pregnancy outside of the womb. Warnings and precautions: Check with your doctor or pharmacist before using Progesterone if you have or ever have had: • liver problems such as jaundice (yellowing of the skin and whites of the eyes) • epilepsy • migraine • asthma • cardiac or renal dysfunction • diabetes Possible side effects : These include drowsiness, stomach discomfort or pain, breast pain, diarrhea, soreness in your rectum (back passage), flatulence (wind), changes in your menstrual and leakage after the pessary has dissolved (this is quite normal when using medicines that are inserted into the vagina or rectum) Other medicines and Progesterone: Tell your doctor or pharmacist if you are taking: • carbamazepine (e.g. to prevent fits, treat certain type of pain or mood disorders), • rifampicin (to treat infections), • phenytoin (e.g. to prevent fits or treat certain type of pain) as they may decrease the effectiveness of Progesterone. Using other vaginal products at the same time as Progesterone is used vaginally is not recommended as it is not known if it affects the treatment. How to use Progesterone: The recommended dose is 200 mg once a day or 400 mg twice a day by vaginal or rectal insertion. The pessary may be inserted into either the vagina or rectum (back passage) depending upon the following certain other conditions. You should insert Progesterone into the: vagina if you have: colitis (inflammation of the colon causing frequent attacks of diarrhea with mucous or blood) problems controlling your bowel movements. rectum (back passage) if you have: a vaginal infection (discharge from your vagina) or often have cystitis (a burning pain on passing water) recently given birth to use a barrier method of birth control such as a diaphragm, cap or condom. For premenstrual tension start using Progesterone on day 12 or 14 of your menstrual cycle. This can be planned and marked onto your calendar, day 1 is the first day of your monthly period, counting forward to day 12 or 14 as advised by your doctor. How to store Progesterone: • Keep this medicine out of the sight and reach of children. • Do not store above 30°C. • Do not use this medicine after the expiry date which is stated on the label/carton/bottle. The expiry date refers to the last day of that month. * Dosage form and route of administration of Progesterone 400mg pessary should be prescribed according to therapeutic indication and disease severity of each individual patient.