Co-Aprovel 300/12.5 mg 28 Tablets

Irbesartan/Hydrochlorothiazide 300/12.5 mg What Irbesartan/Hydrochlorothiazide is used for: It is a combination of Irbesartan, an angiotensin II receptor antagonist, and Hydrochlorothiazide, a thiazide diuretic, indicated for hypertension: In patients not adequately controlled with monotherapy. As initial therapy in patients likely to need multiple drugs to achieve their blood pressure goal. Do not take Irbesartan/Hydrochlorothiazide if: Hypersensitivity to Irbesartan or hydrochlorothiazide Hypersensitivity to sulfonamide-derived drugs (like sulfamethoxazole/trimethoprim, sulfasalazine) Anuria present (not enough urine production) Renal impairment Liver impairment Warnings & Precautions: Talk to your doctor or pharmacist before taking Irbesartan/Hydrochlorothiazide To monitor kidney functions To monitor potassium levels If you have vision problems like myopia or glaucoma If you have lupus If you are at risk to be volume depleted (dehydrated) Possible Side Effects: Fatigue Dizziness Muscle pain Other medicines and Irbesartan/hydrochlorothiazide: Tell your doctor or pharmacist about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Increased risk of kidney damage and reduction of its effects when taken with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and COX-2 inhibitors (like ibuprofen, ketoprfen, celecoxib) Increased risk of lithium toxicity when taken together Not recommended use with potassium supplements to avoid increase of potassium levels in blood. With only Hydrochlorothiazide: Avoid cholestyramine and colestipol to have maximum absorption Adjust dose of antidiabetics Monitor while using alcohol, barbiturates and narcotics because of the potential hypotension How to take Irbesartan/hydrochlorothiazide: Adults above 18 years of age and CrCl >30ml/min: The usual dose is: 1 tablet daily Irbesartan//hydrochlorothiazide tablet can be taken with or without food It may be administered with other antihypertensive agents It can be taken any time of the day Do not break the tablet in half Correct if known volume depletion prior to starting the medicine How to store Irbesartan/hydrochlorothiazide: Keep this medicine out of the sight and reach of children. Store at Room Temperature [77°F (25°C)]. Do not store above 30°