Therapeutic Indications Of XGEVA injection The Xgeva brand of denosumab is used to prevent bone fractures and other skeletal conditions in people with multiple myeloma, and in people with tumors that have spread to the bone. also used to treat giant cell bone tumor in adults and teenagers with fully matured bone structure Method Of Administration Of XGEVA injection Injected under the skin of your stomach, upper thigh, or upper arm. A healthcare provider will give you this injection. Usually given once every 4 weeks. Undesirable Side Effects Of XGEVA injection feeling weak or tired nausea, vomiting, loss of appetite diarrhea, constipation headache, back pain pain or swelling in your arms or legs Warnings & Special Precautions While Taking XGEVA injection You should not receive Xgeva if you are allergic to denosumab, or if you have low levels of calcium in your blood (hypocalcemia). Before you receive this medicine, tell your doctor if you have kidney disease or if you are on dialysis. Some people using Xgeva have developed bone loss in the jaw, also called osteonecrosis of the jaw. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving Xgeva. You may need to stop using the medicine for a short time. Storage Conditions Of XGEVA injection Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the label and carton after EXP. The expiry date refers to the last day of that month. Store in a refrigerator (2°C – 8°C). Do not freeze. Keep the container in the outer carton in order to protect from light. Your pre-filled syringe may be left outside the refrigerator to reach room temperature (up to 25°C) before injection. This will make the injection more comfortable. Once your syringe has been left to reach room temperature (up to 25°C), it must be used within 30 days.