What Solifenacin is used for: Solifenacin belongs to the group of anticholinergics. These medicines are used to reduce the activity of an overactive bladder. This enables you to wait longer before having to go to the bathroom and increases the amount of urine that can be held by your bladder. Solifenacin succinate is used to treat the symptoms of a condition called overactive bladder. These symptoms include: having a strong, sudden urge to urinate without prior warning, having to urinate frequently or wetting yourself because you could not get to the bathroom in time. Do not take Solifenacin succinate if you: are allergic to solifenacin or any of the other ingredients of this medicine (listed in section 6) have an inability to pass water or to empty your bladder completely (urinary retention) have a severe stomach or bowel condition (including toxic megacolon, a complication associated with ulcerative colitis) suffer from the muscle disease called myasthenia gravis, which can cause an extreme weakness of certain muscles suffer or are at risk of suffering from increased pressure in the eyes, with gradual loss of eye sight (glaucoma) are undergoing kidney dialysis have severe liver disease suffer from severe kidney disease or moderate liver disease AND at the same time are being treated with medicines that may decrease the removal of solifenacin from the body (for example, ketoconazole). Your doctor or pharmacist will have informed you if this is the case. Warnings and Precautions: Talk to your doctor or pharmacist before taking Solifenacin succinate if you: have trouble emptying your bladder (bladder obstruction) or have difficulty in passing urine (e.g. a thin urine flow). Risk of accumulation of urine in the bladder (urinary retention) is much higher. have some obstruction of the digestive system (e.g.constipation). are at risk of your digestive system slowing down (stomach and bowel movements). Your doctor will have informed you if this is the case. suffer from severe kidney disease. have moderate liver disease. are taking certain medicines known as CYP3A4 inhibitors (such as ketoconazole ) which may increase the amount of solifenacin in your blood have a stomach tear (hiatus hernia) or heartburn and/or are taking certain medicines (such as biphosphates) that can cause or worsen inflammation of the gullet. have a nervous disorder (autonomic neuropathy). suffer from changes in heart rhythm (seen in ECG) or have low potassium level in your blood. Possible side effects: Stop using the product and seek immediate medical attention if you develop throat tightness or swelling of the eyes, face, lips or tongue, feel faint, or have difficulty breathing. Stop using the product if you develop hives or itching of the face or body. Other medicines and Solifenacin: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. It is especially important to inform your doctor if you are taking: other anticholinergic medicines (such as atropine, oxybutynin, hydroxyzine, bupropion, dextromethorphan) as it may increase the effects and side effects of both medicines. Cholinergics (medicines such as carbachol and pilocarpine) as they can reduce the effect of solifenacin. medicines, like metoclopramide and cisapride, which make the digestive system work faster. Solifenacin can reduce their effect. medicines, like ketoconazole, ritonavir, nelfinavir, itraconazole, verapamil and diltiazem, which decrease the rate at which solifenacin is broken down by the body medicines like rifampicin, phenytoin and carbamazepine, as they may increase the rate at which solifenacin is broken down by the body. How to use Solifenacin: The recommended dose is 5 mg per day, unless your doctor told you to take 10 mg per day. How to store: Keep this medicine out of the sight and reach of children. For bottle pack only: After first opening, use within 100 days. Do not use this medicine after the expiry date which is stated on the carton/blister/bottle after EXP. The expiry date refers to the last day of that month. This medicine does not require any special storage conditions. A valid prescription should be available upon delivery

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