Therapeutic Indications Of TREMFYA Tremfya contains the active substance guselkumab which is a type of protein called a monoclonal antibody. This medicine works by blocking the activity of a protein called IL-23, which is present at increased levels in people with psoriasis and psoriatic arthritis. Method Of Administration Of TREMFYA Your doctor will decide for how long you need to use Tremfya. Plaque psoriasis • The dose is 100 mg (the content of 1 pre-filled syringe) given by injection under the skin (subcutaneous injection). This may be given by your doctor or nurse. • After the first dose, you will have the next dose 4 weeks later, and then every 8 weeks. Psoriatic arthritis • The dose is 100 mg (the content of 1 pre-filled syringe) given by injection under the skin (subcutaneous injection). This may be given by your doctor or nurse. • After the first dose, you will receive the next dose 4 weeks later, and then every 8 weeks. For some patients, after the first dose, Tremfya may be given every 4 weeks. Your doctor will decide how often you may receive Tremfya. Undesirable Side Effects Of TREMFYA headache joint pain (arthralgia) diarrhoea redness, irritation or pain at the injection site increased level of liver enzymes in the blood Warnings & Special Precautions While Taking TREMFYA Talk to your doctor, pharmacist or nurse before using Tremfya: • if you are being treated for an infection • if you have an infection that does not go away or that keeps coming back • if you have tuberculosis or have been in close contact with someone with tuberculosis • if you think you have an infection or have symptoms of an infection (see below under ‘Look out for infections and allergic reactions’) • if you have recently had a vaccination or if you are due to have a vaccination during treatment with Tremfya.