Therapeutic Indications Of TASIGNA capsules
Used to treat a type of leukaemia called Philadelphia chromosome positive chronic myeloid leukaemia (Ph-positive CML)
Method Of Administration Of TASIGNA capsules
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
Use in adults:
- The recommended dose is 600 mg per day. This dose is achieved by taking two hard capsules of 150 mg twice a day.
- The recommended dose is 800 mg per day. This dose is achieved by taking two hard capsules of 200 mg twice a day.
Use in children and adolescents:
- The dose given to your child will depend on your child’s body weight and height. The doctor will calculate the correct dose to use and tell you which and how many capsules of Tasigna to give to your child. The total daily dose you give to your child must not exceed 800 mg.
Your doctor may prescribe a lower dose depending on how you respond to treatment.
- Dosing in pediatric patients is individualized and is based on body surface area (mg/m2), rounded to the nearest 50 mg. Kindly note that the available dosage forms and strengths are 150mg. and 200 mg capsules, 50 mg capsules is not registered in this country.
Older people (age 65 years and over)
Tasigna can be used by people aged 65 years and over at the same dose as for other adults.
Take the hard capsules:
- twice a day (approximately every 12 hours)
- at least 2 hours after any food
- then wait 1 hour before eating again.
Undesirable Side Effects Of TASIGNA capsules
- muscle pain
- itching, rash
- hair loss
- musculoskeletal pain,
Warnings & Special Precautions While Taking TASIGNA capsules
Follow all the doctor’s instructions carefully. They may differ from the general information contained in this leaflet.
a. Do not take Tasigna
- if you are allergic to nilotinib or any of the other ingredients of this medicine (listed in section 6).
If you think you may be allergic, tell your doctor before taking Tasigna.
b. Take special care with Tasigna
Talk to your doctor or pharmacist before taking Tasigna:
- if you have suffered prior cardiovascular events such as a heart attack, chest pain (angina), problems with the blood supply to your brain (stroke) or problems with the blood flow to your leg (claudication) or if you have risk factors for cardiovascular disease such as high blood pressure (hypertension), diabetes or problems with the level of fats in your blood (lipid disorders).
- if you have a heart disorder, such as an abnormal electrical signal called “prolongation of the QT interval”.
- if you are being treated with medicines that affect the heart beat (anti-arrhythmics) or the liver (see Other medicines and Tasigna).
- if you suffer from lack of potassium or magnesium.
- if you have a liver or pancreas disorder.
- if you have symptoms such as easy bruising, feeling tired or short of breath or have experienced repeated infections.
- if you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy).
- if you have ever had or might now have a hepatitis B infection. This is because Tasigna could cause hepatitis B to become active again
Storage Conditions Of TASIGNA Tablets
- Keep this medicine out of the sight and reach of children.
- Do not use this medicine after the expiry date which is stated on the carton and blister. The expiry date refers to the last day of that month.
- Do not store above 30°C.
- Store in the original package in order to protect from moisture.
- Do not use this medicine if you notice that the pack is damaged or shows signs of tampering.
- Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.