Pramipexole 0.7mg tablets What Pramipexole is used for: Pramipexole is used to: treat the symptoms of primary Parkinson’s disease in adults. It can be used alone or in combination with levodopa (another medicine for Parkinson’s disease). treat the symptoms of moderate to severe primary Restless Legs Syndrome in adults. Do not take Pramipexole: • if you are allergic to Pramipexole or any of the other ingredients of this medicine. Warnings and precautions: Talk to your doctor or pharmacist before taking Pramipexole. Tell your doctor if you have (had) or develop any medical conditions or symptoms, especially any of the following: • Kidney disease. • Hallucinations. Most hallucinations are visual. • Abnormal, uncontrolled movements of the limbs (dyskinesia). • Dystonia (inability of keeping your body and neck straight and upright (axial dystonia)). In particular, you may experience forward flexion of the head and neck (also called antecollis), forward bending of the lower back (also called camptocormia) or sideways bending of the back (also called pleurothotonus or Pisa Syndrome). Sleepiness and episodes of suddenly falling asleep. • Psychosis (e.g. comparable with symptoms of schizophrenia). • Vision impairment. Severe heart or blood vessels disease. • Augmentation. Your symptoms may start earlier than usual, be more intense and involve other limbs. Possible side effects: If you suffer from Parkinson’s disease, you may experience the following side effects: Abnormal, uncontrolled movements of the limbs (dyskinesia, sleepiness, dizziness, sickness (nausea), urge to behave in an unusual way, hallucinations (seeing, hearing or feeling things that are not there), confusion, tiredness (fatigue), sleeplessness (insomnia), excess of fluid, usually in the legs (peripheral oedema), headache, low blood pressure (hypotension), abnormal dreams, constipation and visual impairment. If you suffer from Restless Legs Syndrome, you may experience the following side effects: Nausea (sickness), changes in sleep pattern, such as sleeplessness (insomnia) and sleepiness, tiredness (fatigue), headache, abnormal dreams, constipation, dizziness, vomiting (being sick), pathological gambling, especially when taking high doses of Pramipexole, hypersexuality, compulsive shopping and urge to behave in an unusual way. Other medicines and Pramipexole: Tell your doctor or pharmacist if you are taking: cimetidine (to treat excess stomach acid and stomach ulcers) amantadine (which can be used to treat Parkinson’s disease) mexiletine (to treat irregular heartbeats, a condition known as ventricular arrhythmia) zidovudine (which can be used to treat the acquired immune deficiency syndrome (AIDS), a disease of the human immune system) cisplatin (to treat various types of cancers) quinine (which can be used for the prevention of painful night-time leg cramps and for the treatment of a type of malaria known as falciparum malaria (malignant malaria)) procainamide (to treat irregular heartbeat). How to take Pramipexole: You can take Pramipexole with or without food. Swallow the tablets with water. Parkinson’s disease: The daily dose is to be taken divided into 3 equal doses. During the first week, the usual dose is 1 tablet Pramipexole 0.088mg three times a day (equivalent to 0.264mg daily): Lowest maintenance dose Number of tablets: 1 tablet Pramipexole 0.088mg three times a day. Total daily dose (mg): 0.264 Highest maintenance dose Number of tablets: 1 tablet Pramipexole 1.1mg three times a day. Total daily dose (mg): 3.3 Restless Legs Syndrome: The dose is usually taken once a day, in the evening, 2-3 hours before bedtime. During the first week, the usual dose is 1 tablet Pramipexole 0.088mg once a day (equivalent to 0.088mg daily): If you stop taking your tablets for more than a few days and want to restart the treatment, you must start again at the lowest dose. You can then build up the dose again, as you did the first time. Ask your doctor for advice. How to store Pramipexole: Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiration date shown on the package. This medicine does not require any special storage conditions.