Mechanism Of Action Of Mesalazine Mesalazine is an anti-inflammatory drug that acts locally on colonic mucosa to reduce inflammation through a variety of anti-inflammatory processes. This medicine works inside the intestines (bowels) to reduce inflammation associated with multiple diseases. For example, mild to moderately active Crohn's disease, ulcerative colitis, and inflammatory bowel disease Therapeutic Indications Of Salofalk Enema 4 Gm/60 Ml Enema used for the treatment of inflammation of the large intestine (colon) and rectum (back passage) known by doctors as ulcerative colitis. It may be used alone or, particularly in the acute phase, with corticosteroids. It can also be used to control the condition and prevent it from coming back.