Therapeutic Indications Interferon beta-1a is in a class of medications called immunomodulators and is used in adults with relapsing forms of multiple sclerosis to Decrease flare-ups of symptoms (such as balance problems, numbness or weakness) Help to slow disease worsening. Method Of Administration Rebif is intended for subcutaneous (under the skin) injection. The first injection(s) must be performed under the supervision of an appropriately qualified healthcare professional. Dose Patients who have experienced a single clinical event The usual dose is 44 micrograms (12 million IU) given three times per week. Patients with multiple sclerosis The usual dose is 44 micrograms (12 million IU) given three times per week. A lower dose of 22 micrograms (6 million IU) given three times per week is recommended for patients who cannot tolerate the higher dose. Rebif should be administered three times per week, and if possible: · on the same three days every week (at least 48 hours apart, e.g. Monday, Wednesday, Friday) · at the same time of day (preferably in the evening). Use in children and teenagers (2 to 17 years old) No formal clinical studies have been conducted in children or teenagers. However, there is some clinical data available suggesting that the safety profile in children and teenagers receiving Rebif 22 micrograms or Rebif 44 micrograms three times per week is similar to that seen in adults. Use in children (below 2 years of age) Rebif is not recommended for use in children below 2 years of age. Undesirable Side Effects Skin reaction at the site of injection (itching, swelling, color change) Abdominal pain Influenza like symptoms (fever, cough, sore throat, headaches). Warnings & Special Precautions Talk to your doctor or pharmacist before taking Interferon Beta-1a if you: Have depression or suicide signs and symptoms Have liver problems Have bleeding problems or blood clots Have thyroid problems Are at risk for seizures How to store : Keep this medicine out of the sight and reach of children. It should be stored refrigerated between 36°F to 46°F (2°C to 8°C). DO NOT FREEZE The patient may remove it from the refrigerator and store it not above 25°C for one single period of up to 14 days. Store the cartridge in the original package in order to protect from light. Do not use beyond the expiration date printed on packages. Each prefilled syringe and autoinjector is intended for a single dose. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. Are breastfeeding or plan to breastfeed