Pyrazinamide is an antibiotic used to kill or stop the growth of certain bacteria that cause tuberculosis in adults and children. It must be used with other medicines to treat tuberculosis until the disease does not become resistant to treatment. It should be noted that pyrazinamide should not be used in patients with active gout or severe liver disease. Instructions for taking the drug Pyrazinamide How to take: tablets. number of doses: Once a day, or 2 - 3 times a week when higher doses are used. Dosage: Adults —1,000 to 2,000 milligrams (mg) once a day, 1,500 to 3,000 mg three times a week, or 2,000 to 4,000 mg twice a week, depending on your weight. Children: 15-30 mg/kg once a day, with a total dose not exceeding 2,000 mg, or 50 mg/kg twice a week, with a total dose not exceeding 3,000 mg. The beginning of the event: The drug reaches its maximum concentration in the blood within two hours of ingestion. Duration of the event unknown. feed: This medicine can be taken with or without food. Storage and preservation: Store in a closed package in a cool dry place, away from heat and moisture and out of reach of children. Missed dose: Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule without double the dose. Stopping the medication: Even if the patient's condition improves, the entire course of treatment must be completed, as the initial infection may still be in the body and its symptoms may reappear if the drug is discontinued before the end of the specified period of time. overdose: Emergency medical care should be sought in the event of an overdose. Warnings when taking pyrazinamide During pregnancy: Undesirable results have been reported in animal studies, but the effect on pregnant women has not been investigated , so this medicine is not recommended for use during pregnancy. Danger class: Class C. Breast feeding: The drug passes into breast milk, so it is advised to use it with caution only when the benefit to the mother outweighs the risk to the nursing infant. Children and infants Dosage should be reduced and adapted according to age and weight. the elderly: Not given to children. Driving: There are no special problems. Long term use of treatments Surgery and anesthesia: You must inform the doctor about taking the medicine before any operation. Pyrazinamide side effects Nausea or vomiting Prevalence of effect: common Inform the doctor: in severe cases Arthritis Frequency of effect: Rare Inform the doctor: in each case High level of uric acid in the blood Frequency of effect: Rare Inform the doctor: in each case change in skin color Frequency of effect: Rare Inform the doctor: in each case Eye color change Frequency of effect: Rare Inform the doctor: in each case