Pentasa 1Gm 60Tabs

Drug Overview

Pentasa 1000 mg prolonged-release tablets is a gastrointestinal anti-inflammatory medication containing mesalazine (mesalamine), specifically formulated to treat chronic inflammatory bowel diseases. Available through United Pharmacy, Pentasa 1000 mg works directly on the intestinal lining to reduce inflammation, relieve symptoms, and maintain remission in conditions such as ulcerative colitis and Crohn’s disease. Its controlled-release formulation ensures sustained drug delivery throughout the digestive tract.

Active Ingredient and Composition

• Active ingredient: Mesalazine (Mesalamine) 1000 mg
• Dosage form: Prolonged-release tablets
• Pack size: 60 tablets

Mesalazine belongs to the aminosalicylate class and targets inflammation at the mucosal level of the intestine.

Drug Class

• Aminosalicylate anti-inflammatory
• Gastrointestinal anti-inflammatory agent
• Long-acting inflammatory bowel disease (IBD) treatment

Uses and Medical Indications of Pentasa 1000 mg

Pentasa 1000 mg tablets are indicated for:

• Treatment of ulcerative colitis (mild to moderate disease)
• Management of Crohn’s disease
• Maintenance of remission in inflammatory bowel disease (IBD)
• Adjunct therapy with corticosteroids during acute flare-ups

How Pentasa 1000 mg Works

Pentasa 1000 mg delivers mesalazine gradually along the intestine:

• Inhibits inflammatory mediators such as prostaglandins and leukotrienes
• Reduces immune-driven inflammation in the intestinal mucosa
• Provides localized action directly at the site of inflammation

The prolonged-release mechanism allows continuous therapeutic activity in the bowel.

Dosage and Administration of Pentasa 1000 mg

• Maximum recommended dose: up to 4 grams daily
• Active disease: typically 4 g/day, either once daily or divided into multiple doses
• Mild to moderate cases: usually 2 g/day
• Swallow tablets whole with plenty of water
• Do not crush or chew
• Do not double doses if a dose is missed

Dosage should always be individualized based on disease severity and medical advice.

Possible Side Effects

Pentasa 1000 mg is generally well tolerated, but may cause:

• Abdominal pain, diarrhea, nausea, vomiting, bloating, or constipation
• Headache and dizziness
• Skin rash or hypersensitivity reactions
• Rare: chest pain or shortness of breath

Contraindications

Do not use Pentasa 1000 mg if:

• You are allergic to mesalazine or salicylates
• You have severe liver or kidney impairment

Drug Interactions

Pentasa may interact with:

• Corticosteroids (commonly co-administered under supervision)
• Immunosuppressive therapies
• Other salicylate-containing medications

Warnings and Precautions

Use Pentasa 1000 mg with caution in:

• Patients with renal or hepatic impairment
• Individuals with hypersensitivity conditions
• Patients with other chronic diseases requiring monitoring

Regular follow-up and lab monitoring may be necessary during long-term therapy.

Use During Pregnancy and Breastfeeding

• Use during pregnancy only if clearly necessary and under medical supervision
• Mesalazine passes into breast milk; discontinue breastfeeding if the infant develops diarrhea

Use for Children

• Can be used in children under specialist supervision depending on clinical indication

Drug Alternatives

Alternative therapies for inflammatory bowel disease include:

• Sulfasalazine
• Olsalazine
• Corticosteroids (e.g., prednisone)
• Immunomodulators (e.g., azathioprine)

Comparison With Similar Drugs

Compared to other mesalazine formulations, Pentasa 1000 mg:

• Provides extended-release delivery throughout both the small and large intestine
• Offers consistent anti-inflammatory action
• Suitable for both induction and maintenance phases

Safe Usage Tips

• Take medication consistently as prescribed
• Maintain adequate hydration
• Monitor symptoms and report any unusual reactions
• Avoid skipping doses
• Store in a cool, dry place away from children

Frequently Asked Questions (FAQ)

When does Pentasa 1000 mg start working?

Initial improvement may appear within 1 week, but full therapeutic response can take up to 3 months.

Can Pentasa be used with corticosteroids?

Yes, especially during acute flare-ups, under medical supervision.

How long does recovery from colitis take?

Recovery depends on the condition; some forms may improve within 2 weeks, while chronic diseases require ongoing management.

Conclusion

Pentasa 1000 mg prolonged-release tablets is an effective and widely used treatment for inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease. With its targeted, sustained anti-inflammatory action, Pentasa 1000 mg helps control symptoms, maintain remission, and improve patients’ quality of life when used appropriately.