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What Repaglinide is used for: Repaglinide is an oral antidiabetic medicine which helps your pancreas produce more insulin and thereby lower your blood sugar (glucose). Do not take Repaglinide: if you are allergic to Repaglinide or any of the other ingredients in this medicine. if you have type 1 diabetes. if the acid level in your body is raised (diabetic ketoacidosis). if you have a severe liver disease. if you take gemfibrozil (a medicine used to lower increased fat levels in the blood). Warnings and precautions Talk to your doctor or pharmacist before taking Repaglinide: if you have liver problems. Repaglinide is not recommended in patients with moderate liver disease. Repaglinide should not be taken if you have a severe liver disease. if you have kidney problems. Repaglinide should be taken with caution. if you are about to have major surgery or you have recently suffered a severe illness. if you are under 18 or over 75 years of age. Repaglinide is not recommended. Possible Side Effects: Hypoglycemia Hypoglycemic reactions are generally mild/moderate but may occasionally develop into hypoglycemic unconsciousness or coma. If this happens, contact medical assistance immediately. Allergy: Symptoms such as swelling, difficulty in breathing, rapid heartbeat, feeling dizzy and sweating could be signs of anaphylactic reaction. Contact a doctor immediately. Other side effects: Stomach pain Diarrhea. Acute coronary syndrome (but it may not be due to the medicine). Other medicines and Repaglinide: If you take gemfibrozil, you should not take Repaglinide. Your body’s response to Repaglinide may change if you take other medicines, especially these: Monoamine oxidase inhibitors (MAOI) (used to treat depression) Beta blockers (used to treat high blood pressure or heart conditions) ACE-inhibitors (used to treat heart conditions) Salicylates (e.g. aspirin) Octreotide (used to treat cancer) Nonsteroidal anti-inflammatory drugs (NSAID) (a type of painkiller) Steroids (anabolic steroids and corticosteroids – used for anaemia or to treat inflammation) Oral contraceptives (birth control pills) Thiazides (diuretics or “water pills”) Danazol (used to treat breast cysts and endometriosis) Thyroid products (used to treat low levels of thyroid hormones) Sympathomimetics (used to treat asthma) Clarithromycin, trimethoprim, rifampicin (antibiotic medicines) Itraconazole, ketoconazole (antifungal medicines) Gemfibrozil (used to treat high blood fats) Ciclosporin (used to suppress the immune system) Deferasirox (used to reduce chronic iron overload) Phenytoin, carbamazepine, phenobarbital (used to treat epilepsy) St. John’s wort (herbal medicine) Clopidogrel (prevents blood clots) How to take Repaglinide: Always take this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. Your doctor will work out your dose. The normal starting dose is 0.5mg before each main meal. Swallow the tablets with a glass of water immediately before or up to 30 minutes before each main meal. The dose may be adjusted by your doctor up to 4mg to be taken immediately before or up to 30 minutes before each main meal. The maximum recommended daily dose is 16mg. Do not take more Repaglinide than your doctor has recommended. How to store Repaglinide: Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the outer carton, tablet container and the blister after “EXP”. The expiry date refers to the last day of that month. This medicinal product does not require any special storage precautions.