Indapamide 1.5 mg prolonged-release tablets* What Indapamide is used for Indapamide can be used for treating high blood pressure. It may be used on its own or in combination with other medicine for high blood pressure. Most diuretics increase the amount of urine produced by the kidneys. However, indapamide is different from other diuretics, as it only causes a slight increase in the amount of urine produced. In addition, indapamide widens blood vessels so that blood passes through more easily. This helps lower blood pressure. Do not take Indapamide • if you are allergic (hypersensitive) to indapamide, any other sulfonamide or to any of the other ingredients of this medicine. • if you have severe kidney disease • if you have severe liver disease or suffer from a condition called hepatic encephalopathy (liver problems which affect your brain and central nervous system) • if you have low levels of potassium in your blood (hypokalaemia) Warnings and Precautions Talk to your doctor or pharmacist before taking indapamide: • if you suffer from gout or have diabetes • if you have kidney problems • if you have an overactive parathyroid gland (hyperparathyroidism) • if you have heart rhythm problems • if you have liver problems • if you experience a decrease in vision or eye pain • If you earlier have had a penicillin or sulfonamide allergy • If you are an athlete, this may give a positive reaction in doping tests. Possible side effects of Indapamide • Angioedema and/or urticaria • Severe skins reactions • Irregular heartbeat • Severe stomach pain • Abnormal liver function • tiredness, weakness, confusion and muscles that ache, are stiff or do not work well • Irritability and your muscles twitch. • Itchy, lumpy rash • more infections than usual or bruise more easily • increased thirst, hunger and weight loss • photosensitivity reactions • low potassium in the blood • low sodium in the blood • increase in blood glucose levels in diabetic patients • increase of calcium in blood Other medicines and Indapamide Please tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines you buy without a prescription, including herbal medicines. This is because indapamide can affect the way some medicines work. Also, some medicines can affect the way indapamide works including medicines for: • Depression • Heart rhythm problems • heart diseases • constipation • mental disorders • infections • parasitic infestation • allergies • pain • fungal infections • asthma • rheumatoid diseases • gout • multiple sclerosis • immunity suppression • hypertension • diabetes How to take Indapamide • Always take indapamide exactly as your doctor or pharmacist has told you. You should check with your doctor or pharmacist if you are not sure. • Keep taking this medicine until your doctor tells you to stop. It may take several months before this medicine shows its full effect. • Tablets can be taken with or without food • Swallow the tablets whole with a drink of water • The usual dose is one tablet, once a day, taken in the morning How to store Indapamide • Keep out of the reach and sight of children. • Do not use indapamide after the expiry date which is stated on the carton. The expiry date refers to the last day of that month. • Do not use indapamide if you notice that the tablets are crumbling, broken or discolored. • Indapamide tablets do not need any special storage conditions. • Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment. * Dosage form and route of administration of indapamide 1.5mg should be prescribed according to therapeutic indication and disease severity of each individual patient. A valid prescription should be available upon delivery

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