Paracetamol 450 mg/Orphenadrine citrate 35 mg Tablets What is Paracetamol/Orphenadrine used for : This product consists of two active ingredients; paracetamol and orphenadrine. Paracetamol is a medication that belongs to a class of medications known as analgesics (pain relievers) and antipyretics (fever reducers). Orphenadrine citrate is a skeletal muscle relaxant that acts by altering the way your body muscles sense pain and thus helps in decreasing muscle pain. This product is used for the relief of the following indications: Headache (including tension headache and headaches related to spasms of your skeletal muscles in the area of the neck and head) Fever Sprains Strains Pain due to trauma to your trunk, neck, or limbs Back pain due to prolapsed intervertebral disc Do not take Paracetamol/Orphenadrine : If you are allergic to Paracetamol, Orphenadrine, or any of the ingredients in this medicine. Tell your doctor about the allergy and what signs you had. If you are taking other Paracetamol-containing products. Make sure not to exceed the paracetamol dose. If you have Glaucoma (elevated pressure in your eye), an obstruction in your bowel or bladder, an enlarged prostate, spasm in your esophagus, or myasthenia gravis (a neuromuscular disease that causes muscle weakness). If you are pregnant or breastfeeding Do not give this medication to children under 12 years of age. Warnings and precautions : Talk to your doctor or pharmacist if you develop allergic reactions such as shortness of breath, skin rash, swelling of the face or neck, decreased blood pressure, and dizziness. Make sure to tell your doctor if you have heart, kidney, or liver problems, including alcoholic liver disease or if you have mild arthritis (joints inflammation) and need to take painkillers on a daily basis. Long-term use of this medication may be harmful to your liver. Do not take this medication for a long time without talking to your doctor first. If Your doctor recommends taking this medication for a long time, lab tests to monitor for safety should be done. Contact your doctor if symptoms are not relieved. Talk to your doctor before starting this medication if you are taking other medications containing paracetamol or orphenadrine. Do not take other medications containing paracetamol or orphenadrine with this one. If you are aged 65 or older, it is recommended to take lower doses in order to avoid excessive drowsiness. Avoid drinking alcohol when taking this medication. Do not use this medication for other purposes and do not share it with anyone. Possible side effects : Possible side effects include signs of an allergic reaction, like rash and itching. Signs of breathing and respiratory problems like difficulty breathing (more likely to happen if you have previously experienced them after taking similar painkiller medications like aspirin and ibuprofen). Sudden weight loss, upset stomach, nausea, yellowing of the skin and eyes, loss of appetite, and unexplained bleeding or bruising. Common side effects include drowsiness and sedation, dizziness, nausea, weakness and feeling tired, headache, blurred vision, dry mouth. Increased ocular tension, dilation of the pupils, urinary retention or hesitancy, fast heart rate, palpitations, and constipation. Other medicines and Paracetamol/Orphenadrine : Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medications. If you are taking metoclopramide or domperidone (used for vomiting or nausea). If you are taking cholestyramine (used to lower blood cholesterol). If you are taking blood-thinning medications (e.g. warfarin) and you need to take a painkiller every day. Concomitant chronic use of painkillers and blood-thinning medications may increase the risk of bleeding. If you are taking other Paracetamol or orphenadrine-containing medications. If you are taking medications like orphenadrine that may cause side effects, like, drowsiness, constipation, and dry mouth (e.g. phenothiazines, propantheline, narcotic analgesics, some antidepressants) If you are taking alcohol. If you are taking chloramphenicol (antibiotic). If you are taking anticonvulsants. How to take Paracetamol/Orphenadrine : Adults : Take 1 to 2 tablets orally three times per day. Make sure not to exceed the dose. Make sure not to take this medication if you have already taken another product that contains orphenadrine or paracetamol. Make sure not to exceed the daily recommended dose. Take the tablet with or without food. Take a tablet with a full glass of water. Do not give this medication to children under 12 years of age. How to store Paracetamol/Orphenadrine : Keep out of the reach of children and pets Store medication below 25°C in a dry place Do not use beyond the expiry date mentioned on the box Keep the medication in its original packaging to protect it from moisture and light Do not use damaged pills Do not dispose of medication in the wastewater or household waste