One application per 24 hours, at any time suitable for the patient, for as long as facial erythema is present. The maximum daily recommended dose is 1g in total weight. Mirvaso should be applied smoothly and evenly as a thin layer across the entire face avoiding the eyes, eyelids, lips, mouth and membrane of the inner nose. Mirvaso should only be applied over the face. Wash your hands immediately after applying. Mirvaso can be used in conjunction with other cutaneous medicinal products for the treatment of inflammatory lesions of rosacea and with cosmetics. These products should only be applied immediately before the daily application of Mirvaso, they may be used only after the applied Mirvaso has dried. Keep out of the reach and sight of children. Not to be used in children less than 18 years. Do not use if you are allergic to any of the listed ingredients. Do not apply to closed eyes. Mirvaso has not been studied in patients with renal or hepatic impairment. Mirvaso should not be used during pregnancy or breast feeding. Side effects that are considered to be common include redness, itching, flushing and skin burning sensation, all occurring in 1.2 to 3.3% of patients in clinical studies. They are typically mild to moderate in severity, and usually do not require Mirvaso use to be stopped. These side effects can feel like a worsening of your initial symptoms, and it is impossible to predict if you will experience them before you try Mirvaso. For this reason, we recommend that you order just one tube to start with, and use the gel on a small area of the face at first. Unfortunately we are not able to offer a refund for the product if you experience this common and documented side effect.