Product Name Leponex 100 Mg, Antipsychotic, For Mental Disorders - 50 Tablets Scientific Name Clozapine 100 Mg Tablets Category Of Leponex 100 Mg Tablets Antipsychotic Drugs Mechanism Of Action Of Clozapine Clozapine's antipsychotic action is likely mediated through a combination of antagonistic effects at D2 receptors in the mesolimbic pathway and 5-HT2A receptors in the frontal cortex. D2 antagonism relieves positive symptoms while 5-HT2A antagonism alleviates negative symptoms. Therapeutic Indications Of Leponex 100 Mg Tablets Clozapine is used to treat people with schizophrenia for whom other medicines have not worked. Schizophrenia is a mental illness that affects how you think, feel, and behave. You should only use this medicine if you have already tried at least two other antipsychotic medicines, including one of the newer atypical antipsychotics, to treat schizophrenia, and these medicines did not work or caused severe side effects that cannot be treated. Clozapine is also used to treat severe disturbances in the thoughts, emotions, and behavior of people with Parkinson’s disease in whom other medicines have not worked. Method Of Administration Of Leponex 100 Mg Tablets Swallow the tablet with water. Always take the lowest effective dose for you. Treatment of schizophrenia: The usual starting dose is 12.5 mg (one half of a 25 mg tablet) once or twice on the first day followed by 25 mg once or twice on the second day. If tolerated well, your doctor will then gradually increase the dose in steps of 25-50 mg over the next 2-3 weeks until a dose up to 300 mg per day is reached. The effective daily dose is usually between 200 mg and 450 mg, divided into several single doses per day. Some people might need more. A daily dose of up to 900 mg is allowed. Treatment of severe thought disturbances in patients with Parkinson’s disease: The usual starting dose is 12.5 mg (one-half of a 25 mg tablet) in the evening. The effective daily dose is usually between 25 mg and 37.5 mg, taken as one dose in the evening. Doses of 50 mg per day should only be exceeded in exceptional cases. The maximum daily dose is 100 mg. Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions. If you take more than you should, talk to a doctor or go to the hospital straight away. If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose. Do not take a double dose (two doses at the same time) to make up for the forgotten dose. Undesirable Side Effects Of Leponex 100 Mg Tablets Although the following side effects are not common in everyone, some patients may complain from: Severe constipation. Your doctor will have to treat this to avoid further complications Fast heartbeat Pregnancy & Breastfeeding Precautions While Taking Leponex 100 Mg Tablets If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Your doctor will discuss the possible risks and benefits of using this medicine during pregnancy and breast-feeding Non-Pharmacological Treatments & Advice To Improve Mental Health Ginkgo biloba has been studied for its effects on mental health and found to be effective. Gingko Biloba extract can be purchased in liquid or capsule form for example Ginkozac Capsules Some conditions can be triggered by stress. Physical therapy like yoga will be helpful Adequate amount of sleep is very important for your mental health Always take your medications as instructed. Warnings & Special Precautions While Taking Leponex 100 Mg Tablets Talk to your doctor or pharmacist before you take the medication if you: Blood clots or family history of blood clots, as medicines like these, have been associated with the formation of blood clots Glaucoma (increased pressure in the eye) Elevated blood sugar levels, have occurred in patients with or without diabetes mellitus in their medical history Prostate problems or difficulty in urinating Any heart, kidney, or liver disease Chronic constipation or if you are taking medicines that cause constipation (such as Anticholinergics) Galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption Controlled epilepsy Large intestine diseases Abdominal surgery Heart disease or family history of abnormal conduction in the heart is called “prolongation of the QT interval” Risk for having a stroke Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications including over-the-counter non-prescription medicines, prescription medicines, herbal supplements, vitamins, and supplements. Storage Conditions Of Leponex 100 Mg Tablets Store below 25°c Don’t refrigerate Keep this medicine out of the sight and reach of children. Store in the original package to protect from moisture. Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.