Important information
Jemperli can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment with Jemperli has ended.

Call or see your healthcare provider right away if you develop any symptoms of the following problems or if these symptoms get worse:

Lung problems (pneumonitis). Symptoms of pneumonitis may include:

cough
chest pain
shortness of breath
Intestinal problems (colitis) can lead to tears or holes in your intestine. Signs and symptoms of colitis may include:

diarrhea or more bowel movements than usual
stools that are black, tarry, sticky, or have blood or mucus
severe stomach-area (abdomen) pain or tenderness
Liver problems, including hepatitis. Signs and symptoms of liver problems may include:

yellowing of your skin or the whites of your eyes
severe nausea or vomiting
pain on the right side of your stomach area (abdomen)
dark urine (tea colored)
bleeding or bruising more easily than normal
Hormone gland problems (especially the adrenal glands, pituitary, thyroid, and pancreas). Signs and symptoms that your hormone glands are not working properly may include:

headaches that will not go away or unusual headaches
eye sensitivity to light
eye problems
rapid heartbeat
increased sweating
extreme tiredness
weight gain or weight loss
feeling more hungry or thirsty than usual
urinating more often than usual
hair loss
feeling cold
constipation
your voice gets deeper
dizziness or fainting
changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness
Kidney problems, including nephritis and kidney failure. Signs of kidney problems may include:

change in the amount or color of your urine
blood in your urine
swelling in your ankles
loss of appetite
Skin problems. Signs of skin problems may include:

rash
itching
skin blistering or peeling
swollen lymph nodes
painful sores or ulcers in your mouth or your nose, throat, or genital area
fever or flu-like symptoms
Problems in other organs and tissues. These are not all of the signs and symptoms of immune system problems. Call or see your healthcare provider right away for any new or worse signs or symptoms. Signs and symptoms of these problems may include:

chest pain, irregular heartbeat, shortness of breath, swelling of ankles
confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
persistent or severe muscle pain or weakness, muscle cramps
low red blood cells, bruising
Infusion reactions that can sometimes be severe and life-threatening. Signs and symptoms of infusion reactions may include:

chills or shaking
itching or rash
flushing
shortness of breath or wheezing
dizziness
feeling like passing out
fever
back or neck pain
Rejection of a transplanted organ. Your healthcare provider should tell you what signs and symptoms you should report and monitor you, depending on the type of organ transplant that you have had.

Complications, including graft-versus-host-disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be severe and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with Jemperli. Your healthcare provider will monitor you for the following signs and symptoms: skin rash, liver inflammation, stomach area (abdominal) pain, and diarrhea.

Getting medical treatment right away may help keep these problems from becoming more serious.

Your healthcare provider will check you for these problems during treatment. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. If you have severe side effects, your healthcare provider may also need to delay or completely stop treatment.

Before receiving Jemperli
Before you receive Jemperli, tell your healthcare provider if you have any medical conditions, including if you:

have immune system problems, such as Crohn’s disease, ulcerative colitis, or lupus.
have received an organ transplant.
have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic).
have received radiation treatment to your chest area.
have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.
Pregnancy
Tell your healthcare provider if you are pregnant or plan to become pregnant. Jemperli can harm your unborn baby.

Females who are able to become pregnant:

Your healthcare provider will do a pregnancy test before you start treatment.
You should use effective birth control during treatment and for 4 months after your last dose. Talk to your healthcare provider about birth control methods that you can use during this time.
Tell your healthcare provider right away if you think you may be pregnant or if you become pregnant during treatment with Jemperli.
Breastfeeding
Tell your healthcare provider you are breastfeeding or plan to breastfeed. It is not known if Jemperli passes into your breast milk.

Do not breastfeed during treatment and for 4 months after your last dose.
Jemperli pregnancy and breastfeeding warnings (more detail)

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