What is Vildagliptin & Metformin used for: Vildagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1). Incretins help the body produce more insulin only when it is needed and reduce the amount of glucose being produced by the liver when it is not needed. Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis) Method Of Administration Of Jalra M 50/850 Tablets It should be given with meals to reduce the gastrointestinal side effects associated with metformin hydrochloride. It may be initiated at 50mg/500 mg once daily and gradually titrated to a maximum dose of 50mg/1000 mg twice daily after assessing the adequacy of therapeutic response Doses higher than 100mg of vildagliptin are not recommended Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions. If you take more than you should, talk to a doctor or go to the hospital straight away. If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose. Do not take a double dose (two doses at the same time) to make up for the forgotten dose. Undesirable Side Effects Of Jalra M 50/850 Tablets Although the following side effects are not common in everyone, some patients may complain from: Tremor, dizziness, headache Nausea Hypoglycemia Pregnancy & Breastfeeding Precautions While Taking Jalra M 50/850 Tablets If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Your doctor will discuss the possible risks and benefits of using this medicine during pregnancy and breast-feeding Warnings & Special Precautions While Taking Jalra M 50/850 Tablets Talk to your doctor or pharmacist before taking it if you have: Hypersensitivity to vildagliptin or metformin hydrochloride or any of the excipients If you have moderate or severe liver problems Severe renal impairment Congestive heart failure Acute or chronic metabolic acidosis, including lactic acidosis or diabetic ketoacidosis Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications including over-the-counter non-prescription medicines, prescription medicines, herbal supplements, vitamins, and supplements. Storage Conditions Of Jalra M 50/850 Tablets Store below 25°c Don’t refrigerate Keep this medicine out of the sight and reach of children. Store in the original package to protect from moisture. Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month. Metformin decreases the intestinal absorption of glucose Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization