What is HYALGAN®? HYALGAN® is a solution that contains a natural substance called hyaluronate. Hyaluronate is normally found in the fluid that lubricates and cushions your knee joint. HYALGAN® is injected into your knee to relieve pain due to osteoarthritis. HYALGAN® is a treatment option for people who do not get adequate pain relief from simple painkillers (like Tylenol® or Advil®) or from exercise and physical therapy. HYALGAN® injections can be used in addition to prescription pain relievers. Hyalgan box and needle HYALGAN® is injected directly into your knee by your health care provider. HYALGAN® is a 5-injection regimen given at weekly intervals that provides long-lasting pain relief for up to 6 months Some patients get benefits with 3 injections given at weekly intervals* * Some patients may experience benefit with 3 HYALGAN® injections given at weekly intervals. This has been noted in published literature on patients receiving 3 injections who were followed for 60 days. Individual results may vary but HYALGAN® has shown to relieve knee pain for up to 6 months. Brands listed are the registered trademarks of their respective owners.