A combination medicine that contains two blood sugar lowering agents: Pioglitazone: Increases insulin sensitivity in the body and cell response. Metformin: reduces glucose synthesis in the liver, reduces intestinal absorption of glucose, and increases insulin sensitivity. Side effects of Glacira Plus To find out more information about the side effects resulting from the use of pioglitazone, metformin, which represents the scientific name of Glacira Plus, click here to know the side effects of Glacira Plus. What are the uses of Glacier Plus? Controlling blood sugar levels in patients with type 2 diabetes. What are the contraindications of using Glacira Plus? It is forbidden to use the drug without consulting a specialist doctor in the following cases: Hypersensitivity to the components. Diabetic ketoacidosis. Congestive heart failure. Pioglitazone may worsen heart failure. Bladder Cancer. What are the side effects of Glacira Plus? Headache, diarrhea, and nausea. Symptoms of the common cold. What are the precautions for using Glacira Plus? Use under medical supervision in the following cases: a history of pancreatitis; Liver or kidney disease. During pregnancy, the appropriate dose for the body changes every three months. Breastfeeding. Eye problems due to diabetes. What are the drug interactions of Glacira Plus? It is preferable to tell the doctor or pharmacist about all medications, herbs, vitamins, and nutritional supplements before starting treatment. It is recommended not to concomitantly with the following drugs: Concomitant use of this medicine with insulin may increase the risk of serious heart disease. gemfibrozil. morphine. ranitidine. Heart and blood pressure medications (quinidine, nifedipine, digoxin). Antibiotics (rifampin, vancomycin). What are the doses of Glacira Plus and methods of use? Initial dose: Rapid-release tablet, twice a day with food, 15 mg pioglitazone plus 500 mg metformin. What are the dosage forms of Glacira Plus? 15, 500 mg TABLET, FILM COATED What are the storage conditions for Glassera Plus? Store at a temperature below 25 C, away from moisture and direct sunlight.