What is Perampanel used for: Perampanel is a medication that belongs to a class of medications known as “antiepileptics”. It is used as adjunctive treatment of patients who are 12 years of age and older with the following indications: Partial-onset seizures (unusual electrical activity that affects a small part of the brain) with or without secondarily generalized seizures. Primary generalized tonic-clonic seizures (abnormal functioning in both sides of your brain). Do not take Perampanel: If you are allergic to Perampanel, or any of the ingredients in this medicine. Tell your doctor about the allergy and what signs you had. Warnings & Precautions: Talk to your doctor or pharmacist if you develop allergic reactions such as shortness of breath, skin rash, swelling of the face or neck, decreased blood pressure and dizziness. This medication may cause depression, mood changes and suicidal ideation. Contact your doctor if you experience unusual changes in behavior or mood, appearance or worsening of depression, suicidal thoughts, excessive drowsiness or fatigue and weakness or if you experience any of the following signs; trouble sleeping, new or worse anxiety or depression, aggression, panic attacks, agitation, suicidal attempts and an extreme increase in activity and talking (mania). Suicidal thoughts may be caused by factors other than this medicine, your doctor will make sure to assess you for any other possible causes. Make sure to pay attention for any changes in your mood or behavior and keep all follow-up visits with your healthcare provider as scheduled. Contact your healthcare provider between visits as needed, especially if you are concerned about your signs. This medication may cause neurologic side effects. Talk to your doctor if you experience signs like, drowsiness, fatigue, dizziness and gait disturbance. This medication may increase the risk of falls which may lead to bone fractures and other problems. Talk to your doctor if you experience any loss of balance or gait disturbance when taking this medicine. The risk is higher if you are older than 65 years old. Abrupt discontinuation of this medication may increase your risk of having seizures. Do not stop perampanel unless recommended by your doctor. Your doctor may gradually decrease the dose before you completely stop taking it. Before starting the medication, make sure to tell your doctor about all your medical conditions including: depression, mood problems and liver or kidney problems. Make sure to tell your doctor before starting this medicine if you drink alcohol regularly or have previously abused street drugs, prescription medicines or alcohol. Make sure to tell your doctor before starting this medicine if you are pregnant, plan on getting pregnant, think you may be pregnant or are breastfeeding. Make sure not to take medicines that can make you dizzy or drowsy and do not drink alcohol in order not to increase side effects like, drowsiness, dizziness, worsening of your mood, anger, depression and confusion. Possible Side Effects: Possible side effects include signs of an allergic reaction that may affect your liver, skin, kidney, heart and blood cells, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat, swelling of the legs, yellowing of the skin or whites of the eyes, or dark urine. Other signs include vertigo, dizziness, problems with the gait, increased risk of falls, drowsiness, tiredness, mood and behavior changes, difficulty sleeping, unusual changes in behavior or mood, appearance or worsening of depression, panic attacks, irritability, trouble concentrating, aggression, hallucinations, anxiety, suicidal thoughts, memory problems, confusion, anger, excessive drowsiness, or fatigue and weakness. Common side effects include dizziness, headache, weight gain, nausea, drowsiness, tiredness, vomiting, vertigo (sense of spinning), bruising, abdominal pain, walking problems and falls, irritability, anxiety and muscle coordination problems. Other medicines and perampanel: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medications. If you are taking anticonvulsants like, carbamazepine and phenytoin. If you are taking oral contraceptives (used to prevent unwanted pregnancy). If you are taking rifampin (antibiotic). If you are taking St. John’s wort (used to treat depression). How to take Perampanel: Do not stop taking the medication without consulting your doctor first. Abrupt discontinuation of perampanel can worsen your case. This medicine is usually taken once a day at bedtime. Make sure to take your medication as prescribed by your doctor. Do not change the dose without asking your doctor first. Your doctor will tell you how much to take of this medication and when to take it. Your doctor may change doses depending on your clinical status and response to the medication. Do not take for more or less than prescribed by your doctor. If you are taking perampanel oral suspension, start by removing the oral suspension bottle, two syringes and bottle adapter from the medication box, followed by shaking the bottle well before every use and then uncap the bottle and insert the adapter by pressing downward. Once the adapter becomes in place, you cannot remove it anymore. Then check the dose that your healthcare provider prescribed you in milliliters (mL) and locate the number on the oral syringe. Afterwards, make sure to push the syringe’s plunger all the way down and then, insert the syringe into the bottle keeping it upright and the syringe inserted through the opening in the adapter. In order to accurately measure your dose, turn the bottle upside down while keeping the syringe in place and then pull the plunger until you reach the prescribed dose. If you notice air bubbles in the withdrawn dose, press on the plunger all the way down to release the dose again into the bottle and then pull the plunger to withdraw the prescribed dose again. Make sure to look at the white layer at the end of the plunger to verify the dose in mL and not the black layer. In case your prescribed dose is greater than 20 mL, you can measure the dose with 2 syringes or 1 syringe making two steps to withdraw the prescribed dose with the same syringe. Then, turn the bottle right-side up and remove the syringe from the adapter. Make sure to slowly release the medicine into the corner of your mouth until you receive the entire liquid dose. In case you used two syringes to measure your dose, slowly squirt the dose from the first syringe into the corner of your mouth and then slowly squirt the dose of the second syringe into the corner of your mouth again. Finally, in order to keep your syringe clean, fill a cup with tap water after every use, then insert the syringe into the cup and pull the plunger to withdraw the water into the syringe, then push on the plunger all the way down to release the water out of the syringe and into the sink. Make sure to follow the syringe cleaning steps after every use. Make sure to use the oral dosing syringe and the bottle adapter provided with the bottle, do not use a household teaspoon to measure your dose. Do not drink alcohol while taking this medication to avoid excessive drowsiness and dizziness. How to store Perampanel: Store tablets at 20°C to 25°C. Store oral suspension below 30°C. Do not freeze. Make sure to replace the cap of the oral suspension tightly after every use. This medication is a controlled substance because it can lead to drug dependence and abuse, therefore make sure to store your medicine in a safe place to protect it from theft. Do not sell or share this medicine with anyone. Make sure to use the oral suspension within 90 days of opening it. Discard the suspension after that period of time. Keep out of the reach of children and pets. Do not use beyond the expiry date mentioned on the box. Keep medication in its original pack to protect it from moisture and light. Do not use damaged pills. Do not dispose medication in the wastewater or household waste. What is Perampanel used for: Perampanel is a medication that belongs to a class of medications known as “antiepileptics”. It is used as adjunctive treatment of patients who are 12 years of age and older with the following indications: Partial-onset seizures (unusual electrical activity that affects a small part of the brain) with or without secondarily generalized seizures. Primary generalized tonic-clonic seizures (abnormal functioning in both sides of your brain). Do not take Perampanel: If you are allergic to Perampanel, or any of the ingredients in this medicine. Tell your doctor about the allergy and what signs you had. Warnings & Precautions: Talk to your doctor or pharmacist if you develop allergic reactions such as shortness of breath, skin rash, swelling of the face or neck, decreased blood pressure and dizziness. This medication may cause depression, mood changes and suicidal ideation. Contact your doctor if you experience unusual changes in behavior or mood, appearance or worsening of depression, suicidal thoughts, excessive drowsiness or fatigue and weakness or if you experience any of the following signs; trouble sleeping, new or worse anxiety or depression, aggression, panic attacks, agitation, suicidal attempts and an extreme increase in activity and talking (mania). Suicidal thoughts may be caused by factors other than this medicine, your doctor will make sure to assess you for any other possible causes. Make sure to pay attention for any changes in your mood or behavior and keep all follow-up visits with your healthcare provider as scheduled. Contact your healthcare provider between visits as needed, especially if you are concerned about your signs. This medication may cause neurologic side effects. Talk to your doctor if you experience signs like, drowsiness, fatigue, dizziness and gait disturbance. This medication may increase the risk of falls which may lead to bone fractures and other problems. Talk to your doctor if you experience any loss of balance or gait disturbance when taking this medicine. The risk is higher if you are older than 65 years old. Abrupt discontinuation of this medication may increase your risk of having seizures. Do not stop perampanel unless recommended by your doctor. Your doctor may gradually decrease the dose before you completely stop taking it. Before starting the medication, make sure to tell your doctor about all your medical conditions including: depression, mood problems and liver or kidney problems. Make sure to tell your doctor before starting this medicine if you drink alcohol regularly or have previously abused street drugs, prescription medicines or alcohol. Make sure to tell your doctor before starting this medicine if you are pregnant, plan on getting pregnant, think you may be pregnant or are breastfeeding. Make sure not to take medicines that can make you dizzy or drowsy and do not drink alcohol in order not to increase side effects like, drowsiness, dizziness, worsening of your mood, anger, depression and confusion. Possible Side Effects: Possible side effects include signs of an allergic reaction that may affect your liver, skin, kidney, heart and blood cells, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat, swelling of the legs, yellowing of the skin or whites of the eyes, or dark urine. Other signs include vertigo, dizziness, problems with the gait, increased risk of falls, drowsiness, tiredness, mood and behavior changes, difficulty sleeping, unusual changes in behavior or mood, appearance or worsening of depression, panic attacks, irritability, trouble concentrating, aggression, hallucinations, anxiety, suicidal thoughts, memory problems, confusion, anger, excessive drowsiness, or fatigue and weakness. Common side effects include dizziness, headache, weight gain, nausea, drowsiness, tiredness, vomiting, vertigo (sense of spinning), bruising, abdominal pain, walking problems and falls, irritability, anxiety and muscle coordination problems. Other medicines and perampanel: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medications. If you are taking anticonvulsants like, carbamazepine and phenytoin. If you are taking oral contraceptives (used to prevent unwanted pregnancy). If you are taking rifampin (antibiotic). If you are taking St. John’s wort (used to treat depression). How to take Perampanel: Do not stop taking the medication without consulting your doctor first. Abrupt discontinuation of perampanel can worsen your case. This medicine is usually taken once a day at bedtime. Make sure to take your medication as prescribed by your doctor. Do not change the dose without asking your doctor first. Your doctor will tell you how much to take of this medication and when to take it. Your doctor may change doses depending on your clinical status and response to the medication. Do not take for more or less than prescribed by your doctor. If you are taking perampanel oral suspension, start by removing the oral suspension bottle, two syringes and bottle adapter from the medication box, followed by shaking the bottle well before every use and then uncap the bottle and insert the adapter by pressing downward. Once the adapter becomes in place, you cannot remove it anymore. Then check the dose that your healthcare provider prescribed you in milliliters (mL) and locate the number on the oral syringe. Afterwards, make sure to push the syringe’s plunger all the way down and then, insert the syringe into the bottle keeping it upright and the syringe inserted through the opening in the adapter. In order to accurately measure your dose, turn the bottle upside down while keeping the syringe in place and then pull the plunger until you reach the prescribed dose. If you notice air bubbles in the withdrawn dose, press on the plunger all the way down to release the dose again into the bottle and then pull the plunger to withdraw the prescribed dose again. Make sure to look at the white layer at the end of the plunger to verify the dose in mL and not the black layer. In case your prescribed dose is greater than 20 mL, you can measure the dose with 2 syringes or 1 syringe making two steps to withdraw the prescribed dose with the same syringe. Then, turn the bottle right-side up and remove the syringe from the adapter. Make sure to slowly release the medicine into the corner of your mouth until you receive the entire liquid dose. In case you used two syringes to measure your dose, slowly squirt the dose from the first syringe into the corner of your mouth and then slowly squirt the dose of the second syringe into the corner of your mouth again. Finally, in order to keep your syringe clean, fill a cup with tap water after every use, then insert the syringe into the cup and pull the plunger to withdraw the water into the syringe, then push on the plunger all the way down to release the water out of the syringe and into the sink. Make sure to follow the syringe cleaning steps after every use. Make sure to use the oral dosing syringe and the bottle adapter provided with the bottle, do not use a household teaspoon to measure your dose. Do not drink alcohol while taking this medication to avoid excessive drowsiness and dizziness. How to store Perampanel: Store tablets at 20°C to 25°C. Store oral suspension below 30°C. Do not freeze. Make sure to replace the cap of the oral suspension tightly after every use. This medication is a controlled substance because it can lead to drug dependence and abuse, therefore make sure to store your medicine in a safe place to protect it from theft. Do not sell or share this medicine with anyone. Make sure to use the oral suspension within 90 days of opening it. Discard the suspension after that period of time. Keep out of the reach of children and pets. Do not use beyond the expiry date mentioned on the box. Keep medication in its original pack to protect it from moisture and light. Do not use damaged pills. Do not dispose medication in the wastewater or household waste.