What is Epinon? Eplerenone is an aldosterone antagonist that prevents it from binding to mineralocorticoid receptors in the kidneys, heart and blood vessels of the brain. It lowers blood pressure by excreting increased amounts of sodium and water from the body, while potassium is retained. Eplerenone works both as a diuretic and as an antihypertensive drug via this mechanism. What are the uses of Ebonon? Treatment of high blood pressure (may be used alone or with other antihypertensive drugs) Congestive heart failure that occurs after myocardial infarction. What are the contraindications for the use of Epinon? It is contraindicated for all patients with: Serum potassium level more than 5.5 mEq/L Creatinine clearance is less than or equal to 30 mL/min When the patient is given strong cytochrome 3a4 inhibitors such as itraconazole, ketoconazole, troleandomycin, clarithromycin, ritonavir. Type 2 diabetes with microalbuminuria (micral albuminuria) Serum creatinine more than 2.0 mg/dL in males or 1.8 mg/dL in females Creatinine clearance less than 50 mL/min When the patient is taking other potassium-sparing diuretics, eg amiloride, spironolactone, otriamterene. When taking potassium-containing supplements. What are the side effects of Epinon? dizziness; tired feeling, diarrhea, stomach pain; coughing; fever, chills, body aches, flu symptoms; Vaginal bleeding, or breast swelling. What are the precautions for using EPON? Pregnancy: It can be used by pregnant women after consulting a doctor. No harmful effects have been shown on the fetus through studies. Use with caution in lactation: It is not known if it is excreted in breast milk. Use with caution. Serum potassium levels should be measured prior to initiating treatment and should not be prescribed if the potassium level is >5.5 mEq/L. Monitor potassium levels throughout treatment and adjust dose accordingly. Dose adjustment with cytochrome 3a4 inhibitors is minimal. Potassium levels must be constantly monitored, as it causes high potassium levels, especially in patients with renal failure. Use with caution in diabetic patients with congestive heart failure after myocardial infarction. It is used with caution in patients with mild renal failure, and it is not used in cases of severe failure. What are the drug interactions with Ebonon? If you are taking any of the following medicines, tell your doctor or pharmacist that you may need a dose adjustment or certain tests: Potassium-sparing diuretics (such as aldastazid, amiloride, or triamterene) potassium supplements angiotensin receptor antagonists (eg losartan, candesartan, valsartan) Angiotensin converting enzyme inhibitors (eg, enalapril, ramipril, lisinopril) Non-steroidal anti-inflammatory drugs: Concomitant use with spironolactone may cause an increased risk of hyperkalemia (potassium level should be monitored). Strong cytochrome 3a4 inhibitors such as: ketoconazole, itraconazole, as they may increase the level of eplerenone 5-fold, concomitant use is contraindicated. Less potent CYP3A4 inhibitors such as (erythromycin, fluconazole, verapamil, sequavir): may increase the level of eplerenone two-fold. The starting dose is 25 mg/day. Non-steroidal anti-inflammatory drugs: may reduce the antihypertensive effect of eplerenone. Cytochrome 3A4 inducers (eg aminoglutethamide, carbazepine, naphthycillin, nevirapine, phenobarbital, phenytoin, rifamycin): may reduce the level and effect of eplerenone. triamterene spironolactone amiloride What are the pharmaceutical forms of Ebonon? 50 mg tablet What are the storage conditions for EPON? Store at room temperature in a tightly closed container. Keep away from heat and moisture and do not freeze