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What Pioglitazone/Glimepiride is used for Glimepiride and Pioglitazone are oral diabetes medicines that help control blood sugar levels. Pioglitazone/Glimepiride is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Do not takePioglitazone/Glimepiride if you are allergic to Glimepiride, Pioglitazone, or sulfa drugs if you have severe or advanced heart failure if you have active bladder cancer if you have diabetic ketoacidosis Warnings and precautions Talk to your doctor or pharmacist before taking Pioglitazone/Glimepiride if you ever had: Congestive heart failure or heart disease. Fluid retention. Bladder cancer. Liver disease. Kidney disease. A genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (g6pd) deficiency. Eye problems caused by diabetes. A heart attack or stroke. Possible side effects These include hypoglycemia; weight gain; headache; muscle pain; anxiety; depression; fast heartbeat; nausea, diarrhea; or cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat. Other medicines and Pioglitazone/Glimepiride Tell your doctor or pharmacist if you are taking: Strong CYP2C8 Inhibitors. Oral miconazole. Medications that increase the activity of the enzyme CYP2C8 or CYP2C9, such as rifampin. How to take Pioglitazone/Glimepiride Usual Adult Dose for Diabetes Type 2: Individualize dose based on safety, efficacy, and prior therapy. Initial dose: Pioglitazone 30 mg-Glimepiride 2 mg or Pioglitazone 30 mg-Glimepiride 4 mg orally once a day. Maintenance Dose: gradually titrate dose based on adequacy of therapeutic response and tolerability for each component. Take with first meal of the day. For patients switching from a different sulfonylurea, carefully monitor for hypoglycemia for 1 to 2 weeks due to a potential overlapping drug effect. How to store Pioglitazone/Glimepiride Keep this medicine out of the sight and reach of children. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Store Pioglitazone/Glimepiride at 59° to 86°F (15° to 30°C). Keep it in the original container to protect from light.