Therapeutic Indications Of Co-Irbetel 150/12.5 Tablets Treatment of essential hypertension. This fixed-dose combination is indicated in adult patients whose blood pressure is not adequately controlled on irbesartan or hydrochlorothiazide alone High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease. Method Of Administration Of Co-Irbetel 150/12.5 Tablets The tablets can be taken with or without food. Swallow the tablets with a sufficient amount of water (e.g. one glass). If possible, take your daily dose at the same time each day, for example at breakfast time. Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. The recommended starting dose is one tablet once a day. However, if your blood pressure is not controlled, your doctor may decide to change your dose Doses higher than 300 mg irbesartan/25 mg hydrochlorothiazide once daily are not recommended. Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions. If you take more than you should, talk to a doctor or go to the hospital straight away. If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose. Do not take a double dose (two doses at the same time) to make up for the forgotten dose. Undesirable Side Effects Of Co-Irbetel 150/12.5 Tablets Dizziness increases in blood urea nitrogen (BUN), creatinine and creatine kinase orthostatic dizziness headache cough nausea/vomiting hyperkalaemia Warnings & Special Precautions While Taking Co-Irbetel 150/12.5 Tablets Don’t use the drug in the following conditions: Hypersensitivity to the active substances or any of the excipients, or to other sulfonamide-derived substances (hydrochlorothiazide is a sulfonamide-derived substance) Second and third trimesters of pregnancy Severe renal impairment (creatinine clearance < 30 ml/min) Refractory hypokalemia, hypercalcemia Severe hepatic impairment, biliary cirrhosis, and cholestasis The concomitant use of this drug with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines including those used without prescriptions, vitamins & herbal drugs Storage Conditions Of Co-Irbetel 150/12.5 Tablets Store below 25°c Don’t refrigerate Keep this medicine out of the sight and reach of children. Store in the original package to protect from moisture. Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.