Mounjaro (Tirzepatide): A Dual Agonist for Type 2 Diabetes Mellitus
Product Name:
Mounjaro, Pen, 12.5 Mg, Once Weekly - 4 Pen
Scientific Name:
Tirzepatide 12.5 Mg Injection
Category:
Anti-Diabetic Drugs
Mechanism of Action:
Tirzepatide acts as a dual agonist on both GLP-1 and GIP receptors. Its mechanism of action includes the following effects:
Improved Insulin Sensitivity: It enhances insulin sensitivity.
Reduced Glucagon Secretion: It decreases glucagon secretion.
Increased Satiety: It encourages satiety.
Enhanced Insulin Response: It intensifies the insulin response.
Slowed Gastric Emptying: Tirzepatide slows down gastric emptying.
Glucose Control: It lowers fasting and postprandial glucose levels.
Weight Management: It reduces food intake and total body weight.
Therapeutic Indications:
Mounjaro is recommended as an addition to diet and exercise for people with type 2 diabetes mellitus to enhance glycemic control.
Method of Administration:
Follow your doctor’s or pharmacist’s instructions carefully:
Starting Dose: Begin with 2.5 mg subcutaneously once weekly.
Dose Adjustment: After 4 weeks, the dose may be increased to 5 mg subcutaneously once weekly.
Further Adjustments: If additional glycemic control is needed, the dose can be increased by 2.5 mg after taking the current dosage for at least 4 weeks.
Maximum Dose: The highest dose is 15 mg administered subcutaneously once per week.
Administration Time: Take it once a week, with or without meals, at any time of the day.
Injection Sites: Common injection sites include the abdomen, thighs, or upper arm. Do not inject into veins or muscles.
Precautions:Before using the pen for the first time, seek guidance from your doctor or pharmacist.
Rotate injection sites with each dose.
Avoid mixing Tirzepatide with other injected medications (e.g., insulins).
Non-Pharmacological Treatments & Advice For Obese Patients
Generally, weight loss occurs when energy intake is lower than energy expenditure.
People with obesity need to get at least 150 minutes a week of moderate-intensity physical activity to prevent further weight gain or to maintain the loss of a modest amount of weight.
You probably will need to gradually increase the amount you exercise as your endurance and fitness improve.
Even though regular aerobic exercise is the most efficient way to burn calories and shed excess weight, any extra movement helps burn calories.
Park farther from store entrances and take the stairs instead of the elevator.
Gradually increase the number of steps you take daily to reach that goal.
Warnings & Special Precautions While Taking Mounjaro Pre-Filled Pen
Before using Mounjaro, tell your healthcare provider if you have any other medical conditions, including if you:
Personal or family history of medullary thyroid carcinoma.
Known serious hypersensitivity to tirzepatide or any of the
excipients.
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications including over-the-counter non-prescription medicines, prescription medicines, herbal supplements, vitamins, and supplements.
Storage Conditions Of Mounjaro Pre-Filled Pen
MOUNJARO is a clear, colorless to slightly yellow solution.
store in a refrigerator (2°c – 8°c).
Once needed, a single-dose pen can be kept unrefrigerated for up to 21 days at temperatures not higher than 30°C.
Keep this medicine out of the sight and reach of children.
Store in the original package to protect it from moisture.
Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.
Normal Ranges
Random blood sugar test: A blood sample will be taken at a random time. Regardless of when you last ate, a blood sugar level of 200 milligrams per deciliter (mg/dL) or higher suggests diabetes. A blood sugar level of less than 140 mg/dL is normal. A reading between 140 and 199 mg/dL indicates prediabetes
Fasting blood sugar test. A blood sample will be taken after an overnight fast. A fasting blood sugar level of less than 100 mg/dl is normal. A fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes. If it's 126 mg/dL or higher on two separate tests, you may have diabetes.
Oral glucose tolerance test: For this test, you fast overnight, and the fasting blood sugar level is measured. Then you drink a sugary liquid, and blood sugar levels are tested periodically for the next two hours.
