Advagraf contains the active substance tacrolimus. It belongs to a group of medicines called immunosuppressants. After you have had an organ transplanted (liver, kidney), your body's immune system will try to reject the new organ.  Advagraf is used to control this immune reaction and help the body accept the transplanted organ. You can also receive treatment with Advagraf if you have a rejection reaction against a transplanted liver, kidney, heart or another organ, or if you have previously received other treatment that did not work against the immune reaction after the transplant. Advagraf is used in adults.